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Table 1.

Five approaches to legal and safe weight loss.

ApproachesHow
Decrease input Eat less food: habits, social groups Bariatric surgery: restrictive Appetite-suppressing drugs: lorcaserin; phentermine/topiramate (both FDA approved 2012) 
Decrease food absorption Bariatric surgery: malabsorptive Malabsorptive drugs Carbohydrates: Acarbose Fats: Orlistat, bile acid sequestrants Cholesterol: Ezetimibe Change gut flora? 
Increase excretion Glycosuria: potential drugs to inhibit renal reabsorption of glucose 
Convert calories to heat Eat ice Activate brown fat; cold, exercise 
Increase output Move 
ApproachesHow
Decrease input Eat less food: habits, social groups Bariatric surgery: restrictive Appetite-suppressing drugs: lorcaserin; phentermine/topiramate (both FDA approved 2012) 
Decrease food absorption Bariatric surgery: malabsorptive Malabsorptive drugs Carbohydrates: Acarbose Fats: Orlistat, bile acid sequestrants Cholesterol: Ezetimibe Change gut flora? 
Increase excretion Glycosuria: potential drugs to inhibit renal reabsorption of glucose 
Convert calories to heat Eat ice Activate brown fat; cold, exercise 
Increase output Move 
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