AIDS at Home: Art and Everyday Activism, presented at the Museum of the City of New York from May to October 2017, aimed to complement and complicate popular narratives about the history of HIV/AIDS by examining how HIV/AIDS played out in the everyday lives of diverse communities in New York. The exhibition placed works of art alongside documentary photography, film, and archival materials in unique ways to ask visitors to rethink what counts as activism and to reconsider home as a crucial political space. This paper reflects on the ways the curator sought to activate the domestic archive—the everyday ephemera and affects of illness, caretaking, and family life.