This essay first explores how the defining features of comparative-historical analysis (CHA) endow this approach with comparative advantages for substantive research on macro development. It identifies three major traits of CHA that make this tradition an especially powerful approach for the study of development: cased-based research; a focus on context and configurations; and a concern with mechanisms and temporal flow. It then considers what concretely we have learned about the sources of macro development from CHA studies. While some findings are tentative or open to debate, the list of empirical contributions from CHA is quite substantial. Finally, the essay considers some of the frontiers of CHA work on development. Included at this frontier is work on the concept of development itself, displacing the centrality of property institutions with a focus on identity institutions, and moving the focus of analysis from the national level to subnational and supranational levels.