In 1833 the Native American population of California's Central Valley was decimated by an epidemic variously identified as remittent fever, cholera, typhus, or malaria. This article confirms that it was malaria introduced by the Hudson's Bay Company fur brigade led by John Works, based on the conjunction of weather, carriers,a nd contact and on the eyewitness accounts of Works, George Yount, and J.J. Warner. The Indian's catastrophe contributed to the American colonial conquest of the region.

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