Chicana/o historians have transformed understandings of gender, sexuality, race, ethnicity, identity, labor, and space in the United States. In dialogue with the articles for this special issue, my commentary reflects on some of the significant contributions of Chicana/o history, highlighting the themes of complexity and spatial metaphors. I concur with the authors that there still is much historical reconstruction to do, and suggest that this work is important intellectually and politically, given the hostile climate toward Mexicans and immigrants in many parts of the country. This commentary also provides an opportunity to share the course of my scholarly engagement with Chicana/o history and consider its far-reaching influence on my work in the history of medicine and public health in the U.S. West.