... organic chemistry artificial intelligence method pedagogy computing LHASA E. J. Corey EVAN HEPLER-SMITH* A Way of Thinking Backwards Computing and Method in Synthetic Organic Chemistry ABSTRACT This article addresses the history of how chemists designed syntheses of complex molecules during...

...Catherine M. Jackson This essay provides the first historical account of the origins of synthetic organic chemistry, one of the most powerful and productive of late nineteenth-century sciences. It builds on a revised understanding of the program of organic analysis instituted in the early 1830s...