Twenty-first-century capitalism is fundamentally different from the neoliberalism of the late twentieth century. The prominence of finance, intellectual property (IP) protection, and digital platform businesses raises new regulatory challenges. Monopoly dominance has replaced market fundamentalism. This commentary proposes a research agenda for twenty-first-century capitalism in the interests of identifying, examining, and considering a range of potential regulatory and governance solutions to promote social resilience in an anxious world.

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