Forced migrants and refugees are affected by the COVID-19 pandemic in different and often more profound ways than local populations. This article examines the multilayered vulnerabilities these groups face due to forced immobility, precarious legal status, loss of income, and risks of eviction due to lockdown measures, as well as forced return migration. It discusses the public health and socioeconomic implications of each of these contexts, providing examples from different world regions, with a focus on South America. A key conclusion is the importance of providing regularization mechanisms for migrants, as well as including migrant and refugee populations in states’ emergency responses.