Vietnam’s Green Growth Action Plan for the period 2014–2020 sets out an overall plan for the sustainable development of the country. One of the cornerstones of that plan is the development of a greenhouse gas inventory and emission reduction opportunity assessment for Ho Chi Minh City. This provides a basis for the roadmap towards green growth in Ho Chi Minh City, one of Vietnam’s largest cities. Marginal costs of 38 emission reduction measures were determined for two main economy sectors, namely energy (32 measures) and agriculture, forestry, and other land use (6 measures). From that analysis, a marginal abatement cost curve was compiled for the energy sector. The total emission reduction opportunities available in 2020 are estimated to be 8.97 million tCO 2 e, which represents a 14.7% reduction compared to business as usual. Even when the city only implements reduction measures with negative marginal costs (i.e., abatement that saves money), significant reductions of 5.25 MtCO 2 e (8.6% reduction compared to business as usual) would be achieved. There are significant similarities in abatement opportunities between Ho Chi Minh City and Hanoi, Vietnam’s capital. The case study shows significant reduction in greenhouse gas emissions can be achieved in fast-growing cities with an appropriate level of investment and government support.