We describe a series of three experiments in which students develop a model system for measuring the LC50 of household substances, using grass seed as the model organism. Students use statistical methods to compare two samples (using chi-square and Student’s t -tests), conduct a two-level multifactor experiment to look at multiple factors simultaneously and observe interactions, and make serial dilutions to measure the LC50 over a threefold concentration range. The experimental series was very inexpensive to run and tended to provide very successful LC50 measurements.