In traditional microbiology laboratory activities, different strains of bacteria are exposed to UV radiation for varying lengths of time. This article provides information that expands on these activities (or uses them alone) with Caenorhabditis elegans as a model organism with which to study the effects of UV radiation. These activities might be used in an introductory class to teach students the basics of working with C. elegans . In cell biology and microbiology classes, students might learn about how UV radiation can damage cells and cause cancer. These activities can also be used to teach the students about how genetic background can affect the sensitivity to UV radiation. In the laboratory, the students design their own activities by altering the parameters of the basic UV radiation experiment. By performing these laboratory activities, students will learn about UV radiation and about all parts of the scientific process.

Undergraduate biology labs often explore the techniques of data collection but neglect the statistical framework necessary to express findings. Students can be confused about how to use their statistical knowledge to address specific biological questions. Growth in the area of observational ecology requires that students gain experience in sampling design and the scope of inference relevant to observational studies. I developed a laboratory-based guided inquiry that illustrates these concepts by comparing ponderosa pine (Pinus ponderosa) trees in northeastern Washington State. This approach presents a hands-on experience whereby students apply the statistics they learn in the classroom to a field-based investigation, giving students an appreciation of the design and interpretation of observational studies in ecology.

A standard part of biology curricula is a project-based assessment of cell structure and function. However, these are often individual assignments that promote little problem-solving or group learning and avoid the subject of organelle chemical interactions. I evaluate a model-based cell project designed to foster group and individual guided inquiry, and review how the project stimulates problem-solving at a cellular system level. Students begin with four organism cell types, label organelles, describe their structures, and affix chemicals produced or needed for each organelle’s function. Students simulate cell signaling, cell recognition, and transport of molecules through membranes. After describing the project, I present measures of student participation and a rubric, compare individual versus group work, and highlight future modifications, including alignment with the Next Generation Science Standard of “Structure, Function, and Information Processing.”

Guided-inquiry lab activities with bean beetles ( Callosobruchus maculatus ) teach students how to develop hypotheses, design experiments, identify experimental variables, collect and interpret data, and formulate conclusions. These activities provide students with real hands-on experiences and skills that reinforce their understanding of the scientific method and experimental design. This teaching method can easily be adapted to other test organisms or alternative themes.

Implementation of a guided-inquiry lab in introductory biology classes, along with scaffolded instruction, improved students’ understanding of the scientific method, their ability to design an experiment, and their identification of experimental variables. Pre- and postassessments from experimental versus control sections over three semesters showed that most students improved in their understanding of the scientific method and experimental design skills. Students exhibited improvement in their ability to create hypotheses and correctly identify controls and dependent variables. However, students in both groups struggled with the identification of independent variable and controlled variables.

In this guided inquiry, students explore the complex hormonal regulation of the female reproductive cycle using inexpensive ovulation and pregnancy detection kits that are readily available over the counter. This hands-on activity engages students in the practice of doing science as highlighted by the National Science Education Standards . The laboratory approach described is an effective alternative or complement to traditional lecture presentations of this challenging topic. The laboratory activities described are appropriate for both college and high school students, as reproductive physiology is covered in a wide variety of curricula.

Since 1968, biologists have known that termites line up and follow some ballpoint ink lines but not others. Suggestions for class lessons based on this observation have become widespread. However, many of these are incomplete, superficial, conflicting, and/or occasionally inaccurate, and most provide only simple demonstrations or cookbook-style confirmations. Here, we provide added background for this activity to update, clarify, and expand it. Some ways to use termite trail-following to teach fundamental life and physical science concepts through hands-on inquiry are presented, based on our experience with university students and teachers. These activities, adaptable to many instructional levels, range in scope from a single laboratory session to extended investigation.

We describe the concepts and resources presented during a workshop offered to high school biology teachers using sickle cell disease as a theme in a biology course. We provide their pretest and posttest results and reactions.