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single-nucleotide-polymorphisms

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(a) A <b>single</b>-<b>nucleotide</b> <b>polymorphism</b> between a wild-type and a variant gene...
Published: 01 August 2014
Figure 3. (a) A single-nucleotide polymorphism between a wild-type and a variant gene. (b) Possible consequences of SNPs in the resulting polypeptide. Figure 3. (a) A single-nucleotide polymorphism between a wild-type and a variant gene. (b) Possible consequences of SNPs in the resulting More
Journal Articles
The American Biology Teacher (2014) 76 (6): 386–394.
Published: 01 August 2014
...Figure 3. (a) A single-nucleotide polymorphism between a wild-type and a variant gene. (b) Possible consequences of SNPs in the resulting polypeptide. Figure 3. (a) A single-nucleotide polymorphism between a wild-type and a variant gene. (b) Possible consequences of SNPs in the resulting...
Journal Articles
The American Biology Teacher (2020) 82 (2): 104–112.
Published: 01 February 2020
... macroevolutionary scales are ideal for incorporating into evolution curricula. For example, Hoekstra et al. (2006) demonstrated that a single nucleotide mutation in the melanocortin-1 receptor gene ( Mc1r ) of beach mice was responsible for a malfunction of the melanocortin-1 protein, which results in lighter fur...
Journal Articles
The American Biology Teacher (2017) 79 (8): 615–620.
Published: 01 October 2017
... lifespan ( p value is not given). However, not all smokers experience earlier mortality; in fact, a small proportion manage to survive to extreme ages. It has been postulated that these smokers are long-lived because they possess a set of 215 single nucleotide polymorphisms in their genomes, which enables...
Journal Articles
The American Biology Teacher (2018) 80 (3): 198–202.
Published: 01 March 2018
... but may require additional incubation time. After the bacteria have grown on each of the plates, flame an inoculating loop and pick a single colony off of a BHI plate. If possible, try to choose a few different colony morphology types to ensure that representative bacteria are isolated. Transfer...
Journal Articles
The American Biology Teacher (2016) 78 (1): 15–21.
Published: 01 January 2016
..., some genetic and some environmental, the program grew into a robust and engaging data-analysis activity with four primary learning concepts: Students are given a crew member's genomic data report – a set of genetic variants known to influence disease risk. The variants are single-nucleotide...
Journal Articles
The American Biology Teacher (2015) 77 (1): 63–67.
Published: 01 January 2015
... single-nucleotide polymorphisms, fluorescent in situ hybridization (FISH) or chromosomal microarray analysis can be performed. FISH analysis involves identifying specific sequences on chromosomes using a smaller piece of fluorescently labeled DNA that base-pairs with the DNA within the chromosomes...
Journal Articles
The American Biology Teacher (2012) 74 (6): 430.
Published: 01 August 2012
... includes discussions of human genetic variation, single-nucleotide polymorphisms (SNPs), the tree of life, primate phylogeny, mitochondrial DNA, and the dispersal of Homo sapiens . Especially compelling is a segment on lactase persistence, in which Dr. Tishkoff outlines the origin and spread of the...
Journal Articles
The American Biology Teacher (2014) 76 (6): 396–401.
Published: 01 August 2014
... nucleotides, whereas the ones used in Sequencing by Synthesis are reversible. By contrast, both Semiconductor Sequencing and Single Molecule Real Time (SMRT) Sequencing use deoxynucleotides incorporated into the growing DNA strand. BigDye Chain Terminator, Sequencing by Synthesis, and SMRT sequencing all...
Journal Articles
The American Biology Teacher (2013) 75 (9): 682–691.
Published: 01 November 2013
... amplification of VNTR regions from various locations within the VNTR and would not generate a single specific fragment of DNA. As a result, the only properly designed primers will anneal to the 10 nucleotides that bookend the VNTR region. It is suggested that you allow students to draw this conclusion on their...
Journal Articles
The American Biology Teacher (2012) 74 (4): 256–260.
Published: 01 April 2012
... electrophoresis, determine the quantity and size of the PCR product for each set of primers, and compare observed annealing temperature to calculated annealing temperature. References Baker, J.C., Crumley, R.E. & Eckdahl, T.T. (2002). Random amplified polymorphic DNA PCR in the microbiology...
Journal Articles
The American Biology Teacher (2012) 74 (4): 224–230.
Published: 01 April 2012
... the underlying cause of this condition. Again, an important point of emphasis was the potentially devastating consequences of a seemingly minor, single-nucleotide change in the mtDNA sequence. Point mutations such as this may result in dysfunction of an isolated ETC protein, or can alter the structure...
Journal Articles
The American Biology Teacher (2012) 74 (1): 15–19.
Published: 01 January 2012
... example of a single nucleotide substitution causing an amino acid substitution that affects the protein's structure, function, and even electrical charge. This charge difference provides a diagnostic test. Sickle hemoglobin has a substituted neutral valine for the negatively charged glutamic acid in the...
Journal Articles
The American Biology Teacher (2012) 74 (4): 213–223.
Published: 01 April 2012
... interplay has been described between histone post-translational modifications and DNA methylation ( Eden et al., 1998 ; Vaissière et al., 2008 ). A third type of epigenetic modifications is mediated by microRNAs (miRNA), which are ~22 nucleotide-long, single-stranded, noncoding RNA molecules that...
Journal Articles
The American Biology Teacher (2007) 69 (3): 143–147.
Published: 01 March 2007
... Information. (2003). Single Nucleotide Polymorphism. Available online at: http://www. ncbi.nlm.nih.gov/SNP/snp_summary.cgi. Roden, D.M. & George Jr., A.L. (2002). The genetic basis of vari- ability in drug responses. Nature Reviews Drug Discovery, 1(1), 37-44. Roden 1 37 1 Nature Reviews Drug...
Journal Articles
The American Biology Teacher (2007) 69 (7): 422–425.
Published: 01 September 2007
... released, but the cover- age was only 75%. The more recent work avoided the problem of sequencing the Y chromosome by using a female. Comparing the two genomes indicates that the dissimilarity in the genetic variants called SNPs (single nucleotide polymorphisms) is about 1 SNP per 1,000 base pairs, similar...
Journal Articles
The American Biology Teacher (2007) 69 (5): 280–286.
Published: 01 May 2007
... even on the mouthpiece of a telephone (Silverstein, 1996; Wickenheiser, 2002). Forensic analysts make a profile of tandem repeats of nucleotides found in small sections of DNA that are scattered across the chromosomes. Some regions of non-coding DNA sequences are highly polymorphic, so they vary from...
Journal Articles
The American Biology Teacher (2007) 69 (3): 163–168.
Published: 01 March 2007
...David H. Kass References Batzer, M.A., Stoneking, M., Alegria-Hartman, M., Bazan, H., Kass, D.H., Shaikh, T.H., Novick, G.E., loannou, P.A., Scheer, W.D., Herrera, RJ. & Deininger, P.L. (1994). African origin of human-specific polymorphic Alu inser- tions. Proceedings of the National...
Journal Articles
The American Biology Teacher (2006) 68 (5): 269–274.
Published: 01 May 2006
...) exhibits three different single nucleotide substitutions along its DNA sequence. All three of these polymorphisms result in amino acid changes in the receptor protein, and combina- tions of these polymorphisms result in a total of five slight- ly different genetic variations, or haplotypes, in humans. The...
Journal Articles
The American Biology Teacher (2001) 63 (6): 397–403.
Published: 01 August 2001
...). An important resource wvill be a data- base of single nucleotide polymorphisms (SNPs). The goal is to collect perhaps 100,000 to 300,000 single-base variations from several hun- dred people representing diverse ethnic back- grounds. These data will serve as landmarks for a high resolution genome map...