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rna-interference

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Journal Articles
The American Biology Teacher. 2014; 766373–377 doi: https://doi.org/10.1525/abt.2014.76.6.4
Published: 01 August 2014
...Yin Kiong Hoh This article reviews the discovery of RNA interference, its mechanism of action and its functions, and the principles, challenges, and strategies for RNA therapeutics. Figure 2. The microRNA pathway. Figure 2. The microRNA pathway. Figure 1. The mechanism of RNA...
Journal Articles
The American Biology Teacher. 2013; 759698–703 doi: https://doi.org/10.1525/abt.2013.75.9.12
Published: 01 November 2013
...Sibani Sengupta RNA interference (abbreviated RNAi) is a relatively new discovery in the field of mechanisms that serve to regulate gene expression (a.k.a. protein synthesis). Gene expression can be regulated at the transcriptional level (mRNA production, processing, or stability) and at the...
Images
The mechanism of <b>RNA</b> <b>interference</b>.   Figure 1. The mechanism of <b>RNA</b> interfe...
Published: 01 August 2014
Figure 1. The mechanism of RNA interference. Figure 1. The mechanism of RNA interference. Figure 1. The mechanism of RNA interference. Figure 1. The mechanism of RNA interference. More
Journal Articles
The American Biology Teacher. 2017; 793208–223 doi: https://doi.org/10.1525/abt.2017.79.3.208
Published: 01 March 2017
... complex whole worm in situ hybridizations, and RNA interference for gene knock-down experiments are described for each of the four species. Cumulatively, the suggested methods and experiments will facilitate the exploration of animal regeneration biology and promote curiosity-driven, hands-on application...
Journal Articles
The American Biology Teacher. 2018; 808561–569 doi: https://doi.org/10.1525/abt.2018.80.8.561
Published: 01 October 2018
... tools that allowed researchers to alter gene expression in a wide variety of organisms (e.g., RNA interference, or RNAi). While many of these tools were originally established in insect model systems such as the fruit fly Drosophila melanogaster and the flour beetle Tribolium castaneum , they have...
Journal Articles
The American Biology Teacher. 2017; 799787–791 doi: https://doi.org/10.1525/abt.2017.79.9.787
Published: 01 November 2017
...............................7:516-F, 7:538-RL Renal system............................5:387-I Retention............................9:720-RL Reversible Molecular Binding............................9:746-I Ringer............................1:68-TT RNA interference............................3:208-I...
Journal Articles
The American Biology Teacher. 2014; 769643–647 doi: https://doi.org/10.1525/abt.2014.76.9.14
Published: 01 November 2014
...-billed Woodpecker Story .......................3:160-F It’s Not Your Grandmother’s Genetics Anymore! .......................4:224-F Beyond the Central Dogma: Bringing Epigenetics into the Classroom .......................6:365-F RNA Interference: An Instant Update on the Mechanism, Functions...
Journal Articles
The American Biology Teacher. 2013; 759723–727 doi: https://doi.org/10.1525/abt.2013.75.9.20
Published: 01 November 2013
... Making Microscopy Motivating, Memorable, & Manageable for Undergraduate Students with Digital Imaging Laboratories.......................8:578-H The Tongue Map, Real or Not?.......................8:583-H Bringing RNA Interference (RNAi) into the High School Classroom.......................9...
Journal Articles
The American Biology Teacher. 2011; 737426–429 doi: https://doi.org/10.1525/abt.2011.73.7.10
Published: 01 September 2011
... Drosophila genetics and development that the researchers thought this system might give them some clues as to how royalactin produced its effects, and they were right. Using a combination of RNA interference of gene expression and other genetic control factors, they found that royalactin stimulates...
Journal Articles
The American Biology Teacher. 2011; 73286–89 doi: https://doi.org/10.1525/abt.2011.73.2.6
Published: 01 February 2011
... ). RNA revolution. Discover, October, 46—52. Waddington C.H. ( 1953 ). Genetic assimilation of an acquired character . Evolution , 7 , 118 — 126 . Watters E. ( 2006 ). DNA is not destiny. Discover, November, 33—37, 75. Weismann A. ( 1891 ). Essays Upon Heredity and...
Includes: Supplementary data
Journal Articles
The American Biology Teacher. 2010; 724258–260 doi: https://doi.org/10.1525/abt.2010.72.4.11
Published: 01 April 2010
... . Fire A. Xu S. Montgomery M.K. Kostas S.A. Driver S.E. Mello C.C. ( 1998 ). Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans . Nature , 391 , 806 –– 811 . Judson H.F. ( 1979 ). The eighth day of creation: the makers of the...
Journal Articles
The American Biology Teacher. 2010; 724245–251 doi: https://doi.org/10.1525/abt.2010.72.4.9
Published: 01 April 2010
... inhibition: a method whereby small pieces of double-stranded RNA are introduced that trigger the degradation of the homologous mRNA through RNA interference. •• Electroporation: a method that uses electrical current to force pieces of DNA or RNA into cells in a living embryo. •• Knock-out mice: mice...
Journal Articles
The American Biology Teacher. 2008; 708502–505 doi: https://doi.org/10.2307/30163333
Published: 01 October 2008
... 2006 prize announcement for Andrew Fire and Craig Mello implied that RNA interference, too, violated the central dogma - by interrupting the "normal" transfer of information from RNA to protein - URL: nobelprize. org/nobel_prizes/medicine/laureates/2006/illpres/2_central_ dogma.html). All these...
Journal Articles
The American Biology Teacher. 2008; 707405–410 doi: https://doi.org/10.2307/30163312
Published: 01 September 2008
... fluoroquinolones pecifically target prokary- otic DNA, acting against the DNA gyrases that function in the coiling and uncoiling of DNA, blocking its replication. Frequently used fluoroquinolones include ciprofloxacin and levofloxacin. The anti-tuberculosis drug rifampin interferes with messenger RNA synthesis and...
Journal Articles
The American Biology Teacher. 2007; 693139 doi: https://doi.org/10.2307/4452120
Published: 01 March 2007
.... The sgr gene helps break down chlorophyll when leaves and cotyledons senesce. Some plants genetically lose that enzymatic function and "stay green" longer. RNA interference (the method recognized in last year's Nobel Prize) was used to silence the gene in Arabidopsis, which exhibited prolonged...
Journal Articles
The American Biology Teacher. 2003; 653216–221 doi: https://doi.org/10.2307/4451477
Published: 01 March 2003
... and let-7, interfere with RNA by causing the degradation of mRNA. Dicer passes the siRNAs it creates on to another enzyme com- plex called RISC which matches up the siRNAs with complementary mRNA sequences and then destroys the mRNA thus identified. Several of these degradation systems have been found...
Journal Articles
The American Biology Teacher. 2005; 678498–504 doi: https://doi.org/10.2307/4451890
Published: 01 October 2005
... Sargent-I fetch ne:80 72-468 Fax: 800-676-2540 gent= WeVch W bsiotech@wsargentwelch.com _ _ YE RNA ONAt Email b 737 504 THE AMERICAN BIOLOGY TEACHER, VOLUME 67, NO. 8, OCTOBER 2005 ...
Journal Articles
The American Biology Teacher. 2001; 638550–554 doi: https://doi.org/10.2307/4451185
Published: 01 October 2001
... the recapitulation theory, Moore found Haeckel to be guilty mainly of over-speculation, in what was otherwise an admirable attempt to synthesize knowledge of embryology and evo- lution. Much in the way that we use DNA or RNA today in the contin- ued quest to know the past path of evolution (and...
Journal Articles
The American Biology Teacher. 2000; 627520–524 doi: https://doi.org/10.2307/4450961
Published: 01 September 2000
... of bewilder- ment is often generated when we read such articles, when we consider what might be discovered next, what sur- prises are still to be uncovered. Who would have thought that such a thing as RNA interference (RNAi) would exist? RNAi is the posttranscriptional silencing of genes by double...
Journal Articles
The American Biology Teacher. 2001; 636397–403 doi: https://doi.org/10.2307/4451145
Published: 01 August 2001
... difference that everybody knows; junk is kept while garbage is thrown away" (Brenner 1990). Nobel laureate Paul Berg is another scientist who believes that junk DNA has many lessons to teach us. He once gave a talk at the Salk Institute where he described how the SV40 virus can produce two different RNA tran...