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enzymes-and-structural-proteins

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Journal Articles
The American Biology Teacher. 2015; 776445–451 doi: https://doi.org/10.1525/abt.2015.77.6.445
Published: 01 August 2015
... enzyme replacement therapy. Table 4. Patient findings organizational chart. Patient No. GAA Activity Results Color and % Mutation(s) Effect on Protein Structure Predicted Function Age of Onset Symptoms Form of Disease Treatment In this...
Journal Articles
The American Biology Teacher. 2020; 825315–322 doi: https://doi.org/10.1525/abt.2020.82.5.315
Published: 01 May 2020
... green protein that fluoresces under ultraviolet light. Their goal was to design and synthesize a custom crisprRNA that would recognize the GFP gene. When loaded into the Cas9 enzyme, the CRISPR-Cas9 complex could then bind and cut the GFP gene at the specified location. Evidence that the cut had...
Includes: Supplementary data
Journal Articles
The American Biology Teacher. 2020; 825279–288 doi: https://doi.org/10.1525/abt.2020.82.5.279
Published: 01 May 2020
... that a role might be played by some genes located near the CRISPR region. These CRISPR-associated genes (Cas genes) encode protein enzymes and had been discovered by Ruud Jansen back in 2002 ( Jansen et al., 2002 ). Doudna's lab was able to work out the roles of two of the enzymes, but they still...
Journal Articles
The American Biology Teacher. 2019; 819680–685 doi: https://doi.org/10.1525/abt.2019.81.9.680
Published: 01 December 2019
...............................3.169-I Exploring Nutraceuticals to Enhance Scientific Literacy: Aligning with Vision and Change ............................3.176-I Heating Up Enzyme Kinetics: A Safe, Inexpensive & Quantitative Inquiry Activity............................3.187-I Using Shapes & Codes to Teach the...
Journal Articles
The American Biology Teacher. 2019; 816423–429 doi: https://doi.org/10.1525/abt.2019.81.6.423
Published: 01 August 2019
... bioinformatics and computer modeling, in the context of rational drug design, using free online resources such as databases and computer programs. Through the process of learning about computational drug design and drug optimization, students also learn content such as elements of protein structure and protein...
Includes: Supplementary data
Journal Articles
The American Biology Teacher. 2019; 817507–512 doi: https://doi.org/10.1525/abt.2019.81.7.507
Published: 01 September 2019
... increase in intercellular Ca 2+ (part of the secondary messenger system) that can change the activity of membrane-bound enzymes ( Wang et al., 2002 ; Teixeira da Silva & Dobránszki, 2014 ); and altering the secondary structure of cell wall proteins by changing amide I and amide II bonds ( Chowdhury...
Journal Articles
The American Biology Teacher. 2019; 817513–519 doi: https://doi.org/10.1525/abt.2019.81.7.513
Published: 01 September 2019
... using these constructs. We use enzyme proteins as targets for anticancer drugs for the cell parts and intermolecular interactions as a process. We focus on transmembrane transport in multi-drug resistance in cancer treatment as the process. We employ the role of thermodynamics in the Warburg effect in...
Journal Articles
The American Biology Teacher. 2019; 81152–55 doi: https://doi.org/10.1525/abt.2019.81.1.52
Published: 01 January 2019
... replication by DNA polymerases. The other arrows show the direction of transcription by RNA polymerase of the genes for AmpR (a β-lactamase), GFP (the green fluorescent protein), and AraC (the arabinose regulatory protein) from the adjacent promoter sites. Figure 1. Structure of the pGLO plasmid. The “ori...
Journal Articles
The American Biology Teacher. 2018; 809642–648 doi: https://doi.org/10.1525/abt.2018.80.9.642
Published: 01 November 2018
... contain. The primary transcript, alone, does not appear to contain the information for which excisable exons to leave in and which excisable exons to splice out during a particular splicing event. The information stored in a structural gene, so necessary for a protein's primary amino acid sequence...
Journal Articles
The American Biology Teacher. 2018; 808561–569 doi: https://doi.org/10.1525/abt.2018.80.8.561
Published: 01 October 2018
... synthesis: its structure, assumptions and predictions . Proceedings of the Royal Society of London B , 282 , 20151019 . Levsky, J.M. & Singer, R.H. ( 2003 ). Fluorescence in situ hybridization: past, present and future . Journal of Cell Science , 116 , 2833 – 2838 . Lewis, E.B. ( 1978...
Journal Articles
The American Biology Teacher. 2018; 805379–384 doi: https://doi.org/10.1525/abt.2018.80.5.379
Published: 01 May 2018
... understanding of DNA, protein structure, protein synthesis, enzymes, and dialysis. Students were first told that they would replicate a Nobel-winning experiment to tackle an important question in biology—how a polypeptide chain folds into three-dimensional shape to become a functional protein. After reviewing...
Includes: Supplementary data
Journal Articles
The American Biology Teacher. 2018; 80129–34 doi: https://doi.org/10.1525/abt.2018.80.1.29
Published: 01 January 2018
.... Biochemical and structural characterization of any enzyme is dependent on its successful over-expression and solubility. E. coli -based over-expression of a recombinant protein is a basic molecular biology procedure that is used in research laboratories as well as biotechnology industries. Even though...
Includes: Supplementary data
Journal Articles
The American Biology Teacher. 2017; 799702–710 doi: https://doi.org/10.1525/abt.2017.79.9.702
Published: 01 November 2017
... chromosome #2 has the sequence AATG. An individual might have three repeats on one copy of chromosome #2, which would look like this: AATGAATGAATG ( STR Fact Sheet, 2007 ). Since STRs are not genes and as a result are not transcribed and translated into proteins, they have more variability from person to...
Journal Articles
The American Biology Teacher. 2017; 799787–791 doi: https://doi.org/10.1525/abt.2017.79.9.787
Published: 01 November 2017
... Protein structure and function............................4:257-F, 4:257-OL Protein synthesis............................4:257-F, 4:257-OL Quantitative literacy............................7:572-I Race............................7:516-F, 7:525-F, 7:525-OL, 7:538-RL Racism...
Journal Articles
The American Biology Teacher. 2017; 798615–620 doi: https://doi.org/10.1525/abt.2017.79.8.615
Published: 01 October 2017
... chain from Tetrahymena to humans. Research has shown that telomeric DNA is protected by bound proteins ( Gomez et al., 2012 ). Many of these proteins have been characterized with regard to structure and biochemistry. Researchers have proposed various functions for these proteins by looking at the...
Journal Articles
The American Biology Teacher. 2017; 794257–271 doi: https://doi.org/10.1525/abt.2017.79.4.257
Published: 01 April 2017
... potential utility with any protein-related topic, including: enzyme catalysis; genetic disorders; molecular evolution; allele, nucleotide, and polypeptide sequence-structure comparisons; cell signaling and communication; protein misfolding diseases (e.g., Alzheimer-related fibrillar β-amyloid proteins...
Journal Articles
The American Biology Teacher. 2017; 793191–197 doi: https://doi.org/10.1525/abt.2017.79.3.191
Published: 01 March 2017
... from each soil sample. Moreover, there are many bioinformatic resources on the enzyme nitrogenase—for example, available structures in the Protein Data Bank and protein sequences in the National Center for Biotechnical Information (see Supplemental Material Appendix 8)—that could be incorporated into a...
Journal Articles
The American Biology Teacher. 2017; 793208–223 doi: https://doi.org/10.1525/abt.2017.79.3.208
Published: 01 March 2017
... for the WISH protocol. Name Function Tissue specific expression Citation piwi-1 Protein that promotes stem cell maintenance and differentiation. stem cells (neoblasts) Reddien et al., 2005 pc2 Enzyme whose activity is the proteolytic processing of prohormones to mature...
Journal Articles
The American Biology Teacher. 2017; 79295–101 doi: https://doi.org/10.1525/abt.2017.79.2.95
Published: 01 February 2017
... in no scleral ossification; that is, the effect is qualitative: yes/no, tall/short, and so on. Most of the genes discussed so far are likely “structural” genes; that is, their DNA sequences code for the sequences of amino acids in the resulting proteins. Cavefish eye development is also...
Journal Articles
The American Biology Teacher. 2017; 79110–13 doi: https://doi.org/10.1525/abt.2017.79.1.10
Published: 01 January 2017
... skills in undergraduate biology education . CBE Life Sciences Education , 12 , 124 – 128 . Hershey, A.D. & Chase, M. ( 1952 ). Independent functions of viral protein and nucleic acid in growth of bacteriophage . Journal of General Physiology , 36 , 39 – 56 . Jacob, F. & Monod...