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Journal Articles
The American Biology Teacher. 2018; 8012–5 doi: https://doi.org/10.1525/abt.2018.80.1.2
Published: 01 January 2018
... incorporating TBL into an undergraduate cell biology course using cystic fibrosis (CF) as a theme is described. Class content is divided into modules. Each module consists of (1) out-of-class video viewing and reading assignments; (2) individual and team assessments, mini-lectures, and think-pair-share...
Journal Articles
The American Biology Teacher. 2014; 764254–258 doi: https://doi.org/10.1525/abt.2014.76.4.7
Published: 01 April 2014
...Sharon Gusky In this activity, freshman college students learn biotechnology techniques while playing the role of a laboratory technician. They perform simulations of three diagnostic tests used to screen newborns for cystic fibrosis. By performing an ELISA, a PCR analysis, and a conductivity test...
Published: 01 April 2014
Figure 1. Flowchart of the process for screening newborns for cystic fibrosis. Figure 1. Flowchart of the process for screening newborns for cystic fibrosis.
Journal Articles
The American Biology Teacher. 2020; 825279–288 doi: https://doi.org/10.1525/abt.2020.82.5.279
Published: 01 May 2020
... already crossed that line. Although Clevers's experiment was groundbreaking, there is one obvious problem. Every cell in an adult cystic fibrosis patient possesses the faulty CFTR gene. As such, researchers would have to find a way to introduce the CRISPR repair mechanism into every adult cell, or at...
Journal Articles
The American Biology Teacher. 2018; 809697–701 doi: https://doi.org/10.1525/abt.2018.80.9.697
Published: 01 November 2018
...............................7.501-RL Cryopreservation............................3.168-F, 3.168-OL Culture............................7.530-I Curriculum............................1.47-TT, 2.106-RL, 3.168-F, 3.168-OL, 3.191-RL, 4.264-RL Cystic fibrosis............................1.2-F, 1.2-OL Demonstration gardens...
Journal Articles
The American Biology Teacher. 2018; 805379–384 doi: https://doi.org/10.1525/abt.2018.80.5.379
Published: 01 May 2018
... ). This shows that scientific inquiry may not be a logical and linear process starting from a definite question. Moreover, Anfinsen could not have envisaged that his discovery about protein folding would help understand cystic fibrosis, Alzheimer's disease, and mad cow disease; the significance of a...
Includes: Supplementary data
Journal Articles
The American Biology Teacher. 2017; 794253 doi: https://doi.org/10.1525/abt.2017.79.4.253
Published: 01 April 2017
... various diseases. Targeted sequencing of genes such as the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR or the CF gene) further indicates that sequence diversity is rampant. In the CF gene alone, there are tens of thousands of sequence changes, both disease-relevant and neutral. Through...
Journal Articles
The American Biology Teacher. 2017; 797525–537 doi: https://doi.org/10.1525/abt.2017.79.7.525
Published: 01 September 2017
... might find a spelling difference. kelly : That's right. michael : But wait! “spelling difference” sounds scary. I know that a spelling difference in the DNA of a gene might lead to genetic disease—like cystic fibrosis, sickle cell anemia, or even color blindness. kelly : “ Color blindness...
Journal Articles
The American Biology Teacher. 2016; 78167–69 doi: https://doi.org/10.1525/abt.2016.78.1.67
Published: 01 January 2016
... Hampton, T.H. et al. (2014). The microbiome in pediatric cystic fibrosis patients: the role of shared environment suggests a window of intervention. Microbiome, 2 , 14 Should cystic fibrosis patients be prescribed routine treatments to diversify their microbiome? Epidemiology Luth, W. et al. (2013...
Journal Articles
The American Biology Teacher. 2015; 776452–457 doi: https://doi.org/10.1525/abt.2015.77.6.452
Published: 01 August 2015
... example of a mutation within the storyboard. For instance, a student could explore cystic fibrosis, in which a 3-base-pair deletion from the CFTR gene (cystic fibrosis transmembrane conductance regulator) results in a protein that is missing a phenylalanine residue at position 508. This gene encodes for a...
Journal Articles
The American Biology Teacher. 2015; 773178–183 doi: https://doi.org/10.1525/abt.2015.77.3.5
Published: 01 March 2015
... papillomavirus (HPV) Serology Anatomy/microscopy Vaccine development and ethics (Gardasil) Student survey on sexual partners and barrier methods Current statistics and media Cystic fibrosis DNA Mendelian genetics Recombinant DNA/gene therapy Etiology and epidemiology DNA building blocks Phenotypic...
Journal Articles
The American Biology Teacher. 2014; 769643–647 doi: https://doi.org/10.1525/abt.2014.76.9.14
Published: 01 November 2014
... .......................3:196-I Students as Technicians: Screening Newborns for Cystic Fibrosis .......................4:254-I Are They Bloody Guilty? Blood Doping with Simulated Samples .......................5:328-I Bringing Next-Generation Sequencing into the Classroom through a Comparison of Molecular...
Journal Articles
The American Biology Teacher. 2014; 769576–581 doi: https://doi.org/10.1525/abt.2014.76.9.2
Published: 01 November 2014
... sickle cells problems in all environments; probably some resistance to malarial infections but not to malaria itself Table 1. Genes and alleles. The terms gene and allele are often used incorrectly. For example, there is no cystic fibrosis gene; instead, there is a gene that codes for a...
Journal Articles
The American Biology Teacher. 2014; 766379–383 doi: https://doi.org/10.1525/abt.2014.76.6.5
Published: 01 August 2014
... and traits in textbooks (n = number of sentences). Condition or Trait n Percent of total sample Sickle cell anemia 195 4.93 ABO blood type 153 3.87 Cystic fibrosis 153 3.87 Down syndrome 132 3.34 Hemophilia A 109 2.75 Sex determination 103 2.60 DNA...
Journal Articles
The American Biology Teacher. 2012; 745305–309 doi: https://doi.org/10.1525/abt.2012.74.5.4
Published: 01 May 2012
... pathogenesis of cystic fibrosis lung disease. Advanced Drug Delivery Reviews , 54 , 1359–1371. Chang, Y.L., Wang, E.T., Sui, X.H., Zhang, X.X. & Chen, W.X. (2011). Molecular diversity and phylogeny of rhizobia associated with Lablab purpureus (Linn.) grown in Southern China. Systematic and Applied...
Journal Articles
The American Biology Teacher. 2013; 759657–662 doi: https://doi.org/10.1525/abt.2013.75.9.6
Published: 01 November 2013
... of basic biology in everyday life. Prior to starting the laboratory exercises, students were placed in groups and asked to research several human genetic disorders, including DS, cystic fibrosis, muscular dystrophy, celiac disease, sickle cell disease, and polycystic kidney disease. Students were...
Journal Articles
The American Biology Teacher. 2012; 74115–19 doi: https://doi.org/10.1525/abt.2012.74.1.5
Published: 01 January 2012
..., because of segregation of a population or a genetic bottleneck, and this small group tends to intermarry, then this harmful gene mutation may increase in frequency. Since 2001, obstetricians have been discussing and offering cystic fibrosis (CF) carrier testing to all newly pregnant women. The CF...
Journal Articles
The American Biology Teacher. 2011; 733191–192 doi: https://doi.org/10.1525/abt.2011.73.3.14
Published: 01 March 2011
... out by bacteria, called the "auto-inducer," that is used by some pathogenic bacteria, including P. aerogenosa , which kills people with cystic fibrosis. Bassler's research group is developing therapeutics to block what she calls "quorum sensing" to fool bacteria into thinking that they are alone...
Journal Articles
The American Biology Teacher. 2012; 744278–281 doi: https://doi.org/10.1525/abt.2012.74.4.13
Published: 01 April 2012
... now number over 100,000 ( Callaway, 2007 ). This project has been joined by a similar one called Folding@home, which focuses more on proteins of interest in human health. It is associated with Stanford University and emphasizes the fact that many human diseases, including Alzheimer’s, cystic fibrosis...
Journal Articles
The American Biology Teacher. 2010; 724218 doi: https://doi.org/10.1525/abt.2010.72.4.2
Published: 01 April 2010
... color, diabetes, and autism, we could capitalize on students' intuitive understanding that most traits do not exhibit the dichotomous (““either——or””) inheritance of the traits we typically emphasize, such as widow's peaks, cystic fibrosis, and pea color. In fact, most quantitative traits, such as...