Molecular biology topics tend to be abstract and hard to visualize, and consequently pupils form many misconceptions about genetics and molecular biology. We describe how to make a hands-on educational set that provides visual and tactile modeling of DNA replication, transcription, polymerase chain reaction (PCR), and random mutations so that students can examine these processes in detail. The set is inexpensive and easy to make, has been used successfully, and allows for modification to fit individual teachers' needs.