The National Science Foundation’s GK–12 program provides a unique opportunity for STEM collaboration between the K–12 classroom and university research. This partnership benefits students through experiential learning, exposure to research, exceptional mentorship, and preparation for postsecondary education. Additionally, researchers gain valuable skills by explaining difficult scientific concepts to high school students and broadening their exposure to secondary education. We present graduate-research-based activities focused on understanding the genetic causes of Down syndrome. Modification of these activities could accommodate educational levels from middle school to entry-level college biology. This lesson involves several biological and data-collecting techniques. These experiential activities help students understand genetics and Down syndrome, and introduce basic scientific methodology and techniques useful for postsecondary education.