Climate change can drive evolution. This connection is clear both historically and in modern times. The three-lesson curriculum described below provides opportunities for students to make connections between climate change and evolution through various modes of inquiry and self-investigation. Students examine how genetic variation may either facilitate or limit the ability for species to survive changing climates through work with the model organism Drosophila melanogaster . Students are asked to layer new understanding of the mechanisms of evolution onto their observations of genetic variation in fruit fly thermotolerance, and then synthesize this information to make predictions regarding the survival of species threatened by climate change.