An international group of biology education researchers offer their views on areas of scholarship that might positively impact our understanding of teaching and learning in biology and potentially inform practices in biology and life science instruction. This article contains a series of essays on topics that include a framework for biology education research, considerations in the preparation of biology teachers, increasing accessibility to biology for all learners, the role and challenges of language in biology teaching, sociocultural issues in biology instruction, and assisting students in coping with scientific innovations. These contributions are framed by a discussion of the value of defining several potential “grand challenges” in biology education.

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