Tuberculosis (TB) continues to be a serious global health problem, resulting in >1.4 million deaths each year. Of increasing concern is the evolution of antibiotic-resistant strains of the bacterium that causes TB. Using this real-world scenario, we created a 90-minute activity for high school or undergraduate students to use online bioinformatics tools to detect single-nucleotide polymorphisms (SNPs) between a wild-type and a variant Mycobacterium tuberculosis gene that could confer resistance to a commonly used TB antibiotic, rifampin. Students write a scientific explanation, providing evidence and reasoning, to support their claim of antibiotic resistance or susceptibility. The entire lesson can be found online at http://www.stronglab.org/taylor.
Drug-resistant Tuberculosis: A Genetic Analysis Using Online Bioinformatics Tools
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Jessica M. Taylor, Rebecca M. Davidson, Michael Strong; Drug-resistant Tuberculosis: A Genetic Analysis Using Online Bioinformatics Tools. The American Biology Teacher 1 August 2014; 76 (6): 386–394. doi: https://doi.org/10.1525/abt.2014.76.6.6
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