I present a learning cycle that explores different biotechnologies using the process of in situ hybridization as a platform. Students are presented with a cyclopic lamb and must use biotechnology to discover the mechanism behind the deformity. Through this activity, students learn about signal transduction and discover the processes of polymerase chain reaction, gel electrophoresis, restriction enzyme digests and ligations, cloning, and transformation. Students also discover the nature of scientific inquiry and practice hypothetico-deductive reasoning.

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